About TSM image
The Sinclair Method for Alcohol Use Disorders is an evidence-based treatment for problematic drinking developed by Dr. John D. Sinclair. Unlike traditional treatments that require complete abstinence from alcohol, the Sinclair Method allows you to continue drinking alcohol at the beginning of treatment.
In fact, treatment success depends on the continued consumption of alcohol in combination with the prescription medication Nal(trexone).
Nal is at the heart of the Sinclair Method (TSM) for Alcoholism. When you take Nal prior to drinking, it blocks endorphins, the naturally occurring opiates in the brain, from being released when alcohol is consumed.

When the endorphins are blocked, there is little to no “buzz” or rewarding experience, and the alcohol doesn’t make you feel the pleasure that drives you to drink excessively.
Over time, your brain learns not to associate alcohol with pleasure, resulting in reduced cravings and improved control over alcohol use. Nal must be taken at least one hour before your first drink.

  • FDA-approved for Alcohol Dependence in 1994
  • Well tolerated with few side effects
  • Covered by most prescription insurance plans
  • Not habit-forming

    Credit: SinclairMethod.org